gptkbp:instanceOf
|
gptkb:gene
|
gptkbp:alias
|
gptkb:RET_proto-oncogene
gptkb:proto-oncogene_c-RET
|
gptkbp:associatedWith
|
gptkb:lung_adenocarcinoma
gptkb:papillary_thyroid_carcinoma
gptkb:pheochromocytoma
gptkb:Hirschsprung's_disease
gptkb:familial_medullary_thyroid_carcinoma
gptkb:medullary_thyroid_carcinoma
gptkb:multiple_endocrine_neoplasia_type_2
parathyroid adenoma
|
gptkbp:clinicalTrialPhase
|
RET fusion detection
RET mutation analysis
|
gptkbp:discoveredBy
|
gptkb:Takashi_Miyazaki
|
gptkbp:discoveredIn
|
1985
|
gptkbp:encodes
|
gptkb:RET_proto-oncogene_protein
|
gptkbp:Entrez_Gene_ID
|
5979
|
gptkbp:expressedIn
|
neural crest-derived cells
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
gptkbp:function
|
cell signaling
receptor tyrosine kinase activity
|
gptkbp:HGNC_ID
|
9967
|
https://www.w3.org/2000/01/rdf-schema#label
|
RET gene
|
gptkbp:interactsWith
|
gptkb:GDNF
gptkb:GFRα1
gptkb:GFRα2
gptkb:GFRα3
gptkb:GFRα4
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10q11.21
|
gptkbp:mutationAssociatedWith
|
developmental disorders
gain-of-function
loss-of-function
oncogenic transformation
|
gptkbp:OMIM
|
164761
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
|
gptkbp:pathway
|
gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
gptkbp:product
|
RET receptor
|
gptkbp:regulates
|
cell differentiation
cell growth
cell migration
|
gptkbp:target
|
gptkb:cabozantinib
gptkb:pralsetinib
gptkb:selpercatinib
gptkb:vandetanib
|
gptkbp:UniProtID
|
P07949
|
gptkbp:bfsParent
|
gptkb:Multiple_Endocrine_Neoplasia_type_2A
gptkb:Multiple_Endocrine_Neoplasia_type_2B
gptkb:multiple_endocrine_neoplasia_type_2
gptkb:RET_receptor_tyrosine_kinase
|
gptkbp:bfsLayer
|
6
|