RET gene

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias gptkb:RET_proto-oncogene
gptkb:proto-oncogene_c-RET
gptkbp:associatedWith gptkb:lung_adenocarcinoma
gptkb:papillary_thyroid_carcinoma
gptkb:pheochromocytoma
gptkb:Hirschsprung's_disease
gptkb:familial_medullary_thyroid_carcinoma
gptkb:medullary_thyroid_carcinoma
gptkb:multiple_endocrine_neoplasia_type_2
parathyroid adenoma
gptkbp:clinicalTrialPhase RET fusion detection
RET mutation analysis
gptkbp:discoveredBy gptkb:Takashi_Miyazaki
gptkbp:discoveredIn 1985
gptkbp:encodes gptkb:RET_proto-oncogene_protein
gptkbp:Entrez_Gene_ID 5979
gptkbp:expressedIn neural crest-derived cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function cell signaling
receptor tyrosine kinase activity
gptkbp:HGNC_ID 9967
https://www.w3.org/2000/01/rdf-schema#label RET gene
gptkbp:interactsWith gptkb:GDNF
gptkb:GFRα1
gptkb:GFRα2
gptkb:GFRα3
gptkb:GFRα4
gptkbp:locatedOnChromosome gptkb:chromosome_10q11.21
gptkbp:mutationAssociatedWith developmental disorders
gain-of-function
loss-of-function
oncogenic transformation
gptkbp:OMIM 164761
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkbp:pathway gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkbp:product RET receptor
gptkbp:regulates cell differentiation
cell growth
cell migration
gptkbp:target gptkb:cabozantinib
gptkb:pralsetinib
gptkb:selpercatinib
gptkb:vandetanib
gptkbp:UniProtID P07949
gptkbp:bfsParent gptkb:Multiple_Endocrine_Neoplasia_type_2A
gptkb:Multiple_Endocrine_Neoplasia_type_2B
gptkb:multiple_endocrine_neoplasia_type_2
gptkb:RET_receptor_tyrosine_kinase
gptkbp:bfsLayer 6