|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:RET
rearranged during transfection
|
|
gptkbp:associatedWith
|
gptkb:Hirschsprung's_disease
gptkb:familial_medullary_thyroid_carcinoma
gptkb:medullary_thyroid_carcinoma
gptkb:multiple_endocrine_neoplasia_type_2
|
|
gptkbp:clinicalTrialPhase
|
genetic testing for MEN2
|
|
gptkbp:discoveredBy
|
gptkb:Yoshiki_Takahashi
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:encodes
|
gptkb:RET_receptor_tyrosine_kinase
|
|
gptkbp:Entrez_Gene_ID
|
5979
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
gptkb:adrenal_medulla
parathyroid gland
thyroid gland
|
|
gptkbp:function
|
cell signaling
kidney development
neural crest development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:9967
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RET proto-oncogene
|
|
gptkbp:length
|
1114 amino acids
|
|
gptkbp:ligand
|
gptkb:neurturin
gptkb:GDNF
gptkb:persephin
artemin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q11.21
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
gain-of-function
loss-of-function
oncogenic activation
|
|
gptkbp:OMIM
|
164761
|
|
gptkbp:orthologInMouse
|
gptkb:Ret
|
|
gptkbp:orthologInZebrafish
|
ret
|
|
gptkbp:pathway
|
gptkb:PI3K-AKT_signaling_pathway
gptkb:MAPK_signaling_pathway
cell differentiation
cell proliferation
|
|
gptkbp:proteinFamily
|
gptkb:receptor_tyrosine_kinase
extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
|
|
gptkbp:targetOfDrug
|
gptkb:cabozantinib
gptkb:pralsetinib
gptkb:selpercatinib
gptkb:vandetanib
|
|
gptkbp:UniProtID
|
P07949
|
|
gptkbp:bfsParent
|
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|