RET proto-oncogene protein

URI: https://gptkb.org/entity/RET_proto-oncogene_protein
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName Proto-oncogene tyrosine-protein kinase receptor Ret
gptkbp:discoveredIn 1985
gptkbp:encodedBy gptkb:RET_gene
gptkbp:Entrez_Gene_ID ENSG00000165731
gptkbp:expressedIn gptkb:urogenital_system
neural crest-derived cells
gptkbp:formsComplexWith GFRα co-receptors
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function gptkb:receptor_tyrosine_kinase
cell signaling
gptkbp:HGNC_ID 9967
https://www.w3.org/2000/01/rdf-schema#label RET proto-oncogene protein
gptkbp:involvedIn kidney development
development of nervous system
gptkbp:ligand GDNF family ligands
gptkbp:locatedOnChromosome gptkb:chromosome_10q11.21
gptkbp:location gptkb:plasma_membrane
gptkbp:molecularWeight ~120 kDa
gptkbp:mutationAssociatedWith gptkb:Hirschsprung's_disease
gptkb:medullary_thyroid_carcinoma
gptkb:multiple_endocrine_neoplasia_type_2
gptkbp:OMIM 164761
gptkbp:PDB 6Q2J
gptkbp:phosphorylates tyrosine residues
gptkbp:target gptkb:cabozantinib
gptkb:pralsetinib
gptkb:selpercatinib
gptkb:vandetanib
gptkbp:UniProtID P07949
gptkbp:bfsParent gptkb:RET_gene
gptkbp:bfsLayer 7