Statements (109)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:5-HTT
gptkb:SERT |
| gptkbp:associatedWith |
gptkb:depression
gptkb:obsessive-compulsive_disorder anxiety |
| gptkbp:biologicalProcess |
neurotransmitter transport
serotonin uptake |
| gptkbp:encodedBy |
gptkb:SLC6A4
|
| gptkbp:function |
serotonin:sodium symporter activity
Serotonin reuptake transporter |
| gptkbp:gene |
gptkb:SLC6A4
|
| gptkbp:HGNC_ID |
11050
|
| https://www.w3.org/2000/01/rdf-schema#label |
Q9Y2I2
|
| gptkbp:inhibitedBy |
gptkb:tricyclic_antidepressants
gptkb:SSRIs |
| gptkbp:length |
630 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:17q11.2
|
| gptkbp:location |
gptkb:plasma_membrane
integral component of plasma membrane |
| gptkbp:molecularWeight |
70.6 kDa
|
| gptkbp:OMIM |
182138
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:PDB |
5I6X
6VRH 5I8N 5I6Y 5I6Z 5I73 5I74 5I75 5I76 5I77 5I78 5I79 5I7A 5I7B 5I7C 5I7D 5I7E 5I7F 5I7G 5I7H 5I7I 5I7J 5I7K 5I7L 5I7M 5I7N 5I7O 5I7P 5I7Q 5I7R 5I7S 5I7T 5I7U 5I7V 5I7W 5I7X 5I7Y 5I7Z 5I80 5I81 5I82 5I83 5I84 5I85 5I86 5I87 5I88 5I89 5I8A 5I8B 5I8C 5I8D 5I8E 5I8F 5I8G 5I8H 5I8I 5I8J 5I8K 5I8L 5I8M 5I8O 5I8P 5I8Q 5I8R 5I8S 5I8T 5I8U 5I8V 5I8W 5I8X 5I8Y 5I8Z |
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:publicTransit |
neurotransmitter:sodium symporter
|
| gptkbp:RefSeq |
NP_001036.2
|
| gptkbp:structure |
12 transmembrane domains
|
| gptkbp:substrate |
sodium
chloride serotonin |
| gptkbp:UniProt_entry_name |
gptkb:Sodium-dependent_serotonin_transporter
|
| gptkbp:UniProtID |
gptkb:Q9Y2I2
ENSP00000347992 |
| gptkbp:bfsParent |
gptkb:DUSP22
|
| gptkbp:bfsLayer |
7
|