Sodium-dependent serotonin transporter

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:SERT gptkb:solute_carrier_family_6_member_4
gptkbp:associatedWith	gptkb:depression gptkb:autism_spectrum_disorder gptkb:obsessive-compulsive_disorder anxiety disorders
gptkbp:discoveredBy	gptkb:Rudolf_Jaenisch
gptkbp:expressedIn	central nervous system intestinal mucosa
gptkbp:function	serotonin reuptake
gptkbp:gene	gptkb:SLC6A4
https://www.w3.org/2000/01/rdf-schema#label	Sodium-dependent serotonin transporter
gptkbp:inhibitedBy	gptkb:tricyclic_antidepressants gptkb:selective_serotonin_reuptake_inhibitors
gptkbp:locatedOnChromosome	gptkb:17q11.2
gptkbp:location	presynaptic neuron membrane
gptkbp:mechanismOfAction	sodium-dependent transport
gptkbp:molecularWeight	approximately 70 kDa
gptkbp:mutationAssociatedWith	psychiatric disorders altered serotonin levels
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	5I6X
gptkbp:species	gptkb:Homo_sapiens
gptkbp:structure	12 transmembrane domains
gptkbp:targetOfDrug	gptkb:psychostimulants antidepressants
gptkbp:transportation	serotonin chloride ions sodium ions
gptkbp:UniProtID	gptkb:P31645
gptkbp:bfsParent	gptkb:P31645
gptkbp:bfsLayer	7