Protein kinase, AMP-activated, alpha 1 catalytic subunit

URI: https://gptkb.org/entity/Protein_kinase,_AMP-activated,_alpha_1_catalytic_subunit
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:AMPKα1
gptkb:AMPK_alpha-1
gptkb:AMPK_catalytic_subunit_alpha-1
gptkbp:associatedWith gptkb:cancer
gptkb:type_2_diabetes
obesity
gptkbp:biologicalProcess protein serine/threonine kinase activity
gptkbp:component gptkb:AMP-activated_protein_kinase_complex
gptkbp:encodedBy gptkb:PRKAA1_gene
gptkbp:Entrez_Gene_ID 5562
gptkbp:enzymeCommissionNumber gptkb:EC_2.7.11.31
gptkbp:expressedIn gptkb:skeletal_muscle
brain
heart
liver
adipose tissue
gptkbp:function regulation of cellular energy homeostasis
catalytic subunit of AMPK
gptkbp:gene gptkb:PRKAA1
gptkbp:HGNC_ID 9381
https://www.w3.org/2000/01/rdf-schema#label Protein kinase, AMP-activated, alpha 1 catalytic subunit
gptkbp:interactsWith AMPK beta subunit
AMPK gamma subunit
gptkbp:involves fatty acid oxidation
glucose uptake regulation
metabolic stress response
gptkbp:length 548
gptkbp:locatedOnChromosome gptkb:chromosome_5p13.1
gptkbp:molecularWeight 63 kDa
gptkbp:OMIM 602739
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Prkaa1
gptkbp:PDB gptkb:4CFE
5ISO
gptkbp:phosphorylates gptkb:HMG-CoA_reductase
gptkb:acetyl-CoA_carboxylase
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:RefSeq gptkb:NP_006243.2
gptkbp:regulates activated by phosphorylation
activated by AMP
inhibited by ATP
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:Q13131
gptkbp:bfsParent gptkb:PATK
gptkbp:bfsLayer 6