AMP-activated protein kinase complex

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	gptkb:AMP gptkb:ADP
gptkbp:alsoKnownAs	gptkb:AMPK
gptkbp:component	alpha catalytic subunit beta regulatory subunit gamma regulatory subunit
gptkbp:discoveredBy	gptkb:D._Grahame_Hardie
gptkbp:discoveredIn	1980s
gptkbp:encodedBy	gptkb:PRKAA1 gptkb:PRKAA2 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:PRKAG1 gptkb:PRKAG2 gptkb:PRKAG3
gptkbp:foundIn	eukaryotic cells
gptkbp:function	regulation of cellular energy homeostasis
gptkbp:GO_term	GO:0004672 (protein kinase activity)
gptkbp:inhibitedBy	gptkb:ATP
gptkbp:involvedIn	gptkb:cancer gptkb:type_2_diabetes obesity exercise response response to metabolic stress
gptkbp:OMIM	602739
gptkbp:orthologIn	gptkb:yeast_SNF1_complex
gptkbp:phosphorylates	gptkb:HMG-CoA_reductase gptkb:acetyl-CoA_carboxylase
gptkbp:Reactome	gptkb:R-HSA-1632852
gptkbp:regulates	gptkb:mTOR_pathway cell proliferation lipid metabolism cell growth glucose uptake protein synthesis autophagy fatty acid oxidation insulin sensitivity mitochondrial biogenesis
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:target	gptkb:AICAR gptkb:metformin gptkb:thiazolidinediones
gptkbp:UniProtID	gptkb:Q13131
gptkbp:bfsParent	gptkb:PRKAA1 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:Protein_kinase,_AMP-activated,_alpha_1_catalytic_subunit
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	AMP-activated protein kinase complex