|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:AMPK_alpha-1
gptkb:AMPK_catalytic_subunit_alpha-1
gptkb:AMPK1A
gptkb:AMPKA1
gptkb:MGC138378
MGC138376
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:discoveredBy
|
gptkb:D._Grahame_Hardie
|
|
gptkbp:encodes
|
gptkb:AMP-activated_protein_kinase_catalytic_subunit_alpha-1
|
|
gptkbp:Entrez_Gene_ID
|
5562
ENSG00000132356
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
adipose tissue
|
|
gptkbp:firstDescribed
|
1996
|
|
gptkbp:function
|
regulation of cellular energy homeostasis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9381
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PRKAA1 gene
|
|
gptkbp:length
|
548 amino acids
~39 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5p13.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cardiovascular_disease
insulin resistance
|
|
gptkbp:numberOfExons
|
12
|
|
gptkbp:OMIM
|
602739
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Prkaa1
|
|
gptkbp:pathway
|
AMPK signaling pathway
metabolic pathways
insulin signaling pathway
|
|
gptkbp:product
|
gptkb:AMPK_alpha-1
|
|
gptkbp:proteinFamily
|
gptkb:Serine/threonine_protein_kinase_family
C-terminal domain
protein kinase domain
autoinhibitory domain
|
|
gptkbp:regulates
|
lipid metabolism
cell growth
glucose uptake
autophagy
fatty acid oxidation
mTOR signaling
|
|
gptkbp:UniProtID
|
gptkb:Q13131
|
|
gptkbp:bfsParent
|
gptkb:Protein_kinase,_AMP-activated,_alpha_1_catalytic_subunit
|
|
gptkbp:bfsLayer
|
7
|