Polycomb Repressive Complex 1 (PRC1)

URI: https://gptkb.org/entity/Polycomb_Repressive_Complex_1_(PRC1)
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:amendedBy gptkb:histone_H2A
gptkbp:associatedWith gptkb:Polycomb_group_proteins
gptkbp:catalyzes gptkb:ubiquitin_ligase
gptkbp:component gptkb:PCGF_proteins
gptkb:CBX_proteins
gptkb:PHC_proteins
gptkb:RING1A
gptkb:RING1B
BMI1
gptkbp:discoveredBy gptkb:Drosophila_melanogaster
gptkbp:function gene silencing
chromatin modification
https://www.w3.org/2000/01/rdf-schema#label Polycomb Repressive Complex 1 (PRC1)
gptkbp:involves gptkb:X-chromosome_inactivation
stem cell maintenance
epigenetic regulation
developmental gene regulation
gptkbp:locale gptkb:nucleus
gptkbp:modification_site lysine 119 of histone H2A
gptkbp:modification_type monoubiquitination
gptkbp:opposedBy gptkb:Trithorax_group_proteins
gptkbp:orthologIn gptkb:PRC1_complex
gptkbp:orthologInMouse gptkb:PRC1_complex
gptkbp:recruited_by gptkb:H3K27me3_mark
gptkbp:regulates gptkb:HOX_gene_clusters
cell differentiation
cell proliferation
gptkbp:relatedTo gptkb:Polycomb_Repressive_Complex_2_(PRC2)
gptkbp:role_in_cancer tumor suppressor
gptkbp:subspecies gptkb:canonical_PRC1
non-canonical PRC1
gptkbp:bfsParent gptkb:KDM2B
gptkb:Polycomb-group_(PcG)_protein_family
gptkbp:bfsLayer 7