Polycomb-group (PcG) protein family

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:amendedBy	histone H2A lysine 119 (H2AK119) histone H3 lysine 27 (H3K27)
gptkbp:associatedWith	gptkb:X-chromosome_inactivation imprinting tumorigenesis transcriptional repression chromatin compaction
gptkbp:component	gptkb:Polycomb_Repressive_Complex_1_(PRC1) gptkb:Polycomb_Repressive_Complex_2_(PRC2)
gptkbp:contains	RING finger proteins SET domain proteins WD40 repeat proteins chromodomain proteins
gptkbp:discoveredIn	gptkb:Drosophila_melanogaster
gptkbp:enemyOf	gptkb:Trithorax-group_(TrxG)_protein_family
gptkbp:firstDescribed	1978
gptkbp:foundIn	animals fungi plants
gptkbp:function	epigenetic gene silencing
https://www.w3.org/2000/01/rdf-schema#label	Polycomb-group (PcG) protein family
gptkbp:includes	gptkb:EED gptkb:EZH2 gptkb:CBX_proteins gptkb:Enhancer_of_zeste_(E(z)) gptkb:Extra_sex_combs_(Esc) gptkb:PHC_proteins gptkb:Polycomb_(Pc) gptkb:Polyhomeotic_(Ph) gptkb:Posterior_sex_combs_(Psc) gptkb:RING1A gptkb:RING1B gptkb:Suppressor_of_zeste_12_(Su(z)12) BMI1
gptkbp:mechanismOfAction	histone modification chromatin remodeling
gptkbp:namedAfter	gptkb:Polycomb_gene
gptkbp:regulates	Hox gene expression
gptkbp:role	gptkb:cancer development cell fate determination stem cell maintenance
gptkbp:studiedIn	gptkb:Drosophila_melanogaster gptkb:Arabidopsis_thaliana mammals
gptkbp:bfsParent	gptkb:Ezh6
gptkbp:bfsLayer	6