|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:abnormalExpressionLinkedTo
|
gptkb:cancer
leukemia
congenital malformations
|
|
gptkbp:arrangedInOrder
|
colinearity with body axis
|
|
gptkbp:chromosomeLocationHOXA
|
gptkb:chromosome_7
|
|
gptkbp:chromosomeLocationHOXB
|
gptkb:chromosome_17
|
|
gptkbp:chromosomeLocationHOXC
|
gptkb:chromosome_12
|
|
gptkbp:chromosomeLocationHOXD
|
chromosome 2
|
|
gptkbp:conservedIn
|
bilaterian animals
|
|
gptkbp:contains
|
gptkb:HOX_genes
|
|
gptkbp:discoveredBy
|
gptkb:Edward_B._Lewis
|
|
gptkbp:encodes
|
DNA-binding proteins
|
|
gptkbp:evolvesFrom
|
gene duplication
|
|
gptkbp:expressedIn
|
embryogenesis
|
|
gptkbp:firstDescribed
|
1978
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
body plan specification
anterior-posterior axis patterning
|
|
gptkbp:geneType
|
homeobox gene
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HOX gene clusters
|
|
gptkbp:involvedIn
|
organogenesis
nervous system development
limb development
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:namesOfHumanClusters
|
gptkb:HOXA
gptkb:HOXB
gptkb:HOXC
gptkb:HOXD
|
|
gptkbp:NobelPrizeYear
|
Edward B. Lewis, 1995 Nobel Prize in Physiology or Medicine
|
|
gptkbp:numberOfClustersInHumans
|
4
|
|
gptkbp:numberOfGenesInHumanClusters
|
39
|
|
gptkbp:orthologIn
|
gptkb:zebrafish
gptkb:Drosophila_melanogaster
humans
mice
|
|
gptkbp:presentIn
|
invertebrates
vertebrates
|
|
gptkbp:regulates
|
embryonic development
yes
epigenetic mechanisms
segment identity
retinoic acid
microRNAs
|
|
gptkbp:relatedTo
|
ParaHox gene cluster
|
|
gptkbp:studiedBy
|
knockout mice
transgenic animals
|
|
gptkbp:studiedIn
|
evolutionary developmental biology
|
|
gptkbp:bfsParent
|
gptkb:Polycomb_Repressive_Complex_1_(PRC1)
|
|
gptkbp:bfsLayer
|
8
|