Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:PTP1B
PTPN1 protein |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:type_2_diabetes obesity insulin signaling pathway |
| gptkbp:discoveredBy |
Nicholas K. Tonks
|
| gptkbp:discoveredIn |
1988
|
| gptkbp:enzymeClassification |
EC 3.1.3.48
|
| gptkbp:fullName |
gptkb:Protein_Tyrosine_Phosphatase,_Non-Receptor_Type_1
|
| gptkbp:function |
dephosphorylation of tyrosine residues in proteins
|
| gptkbp:gene |
gptkb:PTPN1
|
| https://www.w3.org/2000/01/rdf-schema#label |
PTP D1
|
| gptkbp:inhibitedBy |
Sodium orthovanadate
Trodusquemine |
| gptkbp:locatedOnChromosome |
gptkb:20q13.13
|
| gptkbp:location |
gptkb:endoplasmic_reticulum
gptkb:cytoplasm |
| gptkbp:molecularWeight |
50 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:regulates |
cell differentiation
cell growth metabolic signaling |
| gptkbp:structure |
contains a single PTP domain
|
| gptkbp:substrate |
gptkb:JAK2
gptkb:EGFR gptkb:insulin_receptor |
| gptkbp:UniProtID |
gptkb:P18031
|
| gptkbp:bfsParent |
gptkb:PTPN17
gptkb:PTPN19 |
| gptkbp:bfsLayer |
7
|