Polycomb repressive complex 2
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:PRC2
|
| gptkbp:associatedWith |
gptkb:X-chromosome_inactivation
imprinting tumorigenesis |
| gptkbp:catalyzes |
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
| gptkbp:component |
gptkb:EED
gptkb:RBBP7 gptkb:EZH2 gptkb:AEBP2 gptkb:JARID2 gptkb:SUZ12 gptkb:RBBP4 |
| gptkbp:discoveredIn |
gptkb:Drosophila_melanogaster
|
| gptkbp:function |
histone methyltransferase
|
| gptkbp:GO_term |
GO:0035097
|
| gptkbp:inhibitedBy |
EZH2 inhibitors
|
| gptkbp:involvedIn |
development
cancer progression stem cell maintenance epigenetic regulation |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:orthologIn |
gptkb:Polycomb_group_proteins
|
| gptkbp:regulates |
gene silencing
chromatin structure |
| gptkbp:relatedTo |
gptkb:Polycomb_repressive_complex_1
|
| gptkbp:UniProtID |
Q15910 (EZH2)
|
| gptkbp:bfsParent |
gptkb:ANRIL
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
Polycomb repressive complex 2
|