|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:Peroxisome_proliferator-activated_receptor_gamma
gptkb:NR1C3
gptkb:PPAR-gamma
|
|
gptkbp:alternativeSplicing
|
gptkb:PPARG1
gptkb:PPARG2
gptkb:PPARG3
gptkb:PPARG4
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
gptkb:familial_partial_lipodystrophy
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:coactivator
|
gptkb:PPARGC1A
gptkb:RXRA
|
|
gptkbp:discoveredBy
|
gptkb:Issemann_and_Green
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
gptkb:Peroxisome_proliferator-activated_receptor_gamma_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000132170
5468
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
colon
macrophages
|
|
gptkbp:fullName
|
gptkb:Peroxisome_proliferator-activated_receptor_gamma
|
|
gptkbp:function
|
transcription factor
nuclear receptor
|
|
gptkbp:HGNC_ID
|
9236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PPARG
|
|
gptkbp:ligand
|
gptkb:thiazolidinediones
fatty acids
eicosanoids
|
|
gptkbp:locatedOnChromosome
|
3
3p25.2
|
|
gptkbp:MIM_gene
|
601487
|
|
gptkbp:OMIM
|
601487
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Pparg
|
|
gptkbp:proteinFamily
|
gptkb:nuclear_hormone_receptor_family
|
|
gptkbp:regulates
|
cell differentiation
lipid metabolism
glucose metabolism
inflammation
insulin sensitivity
adipogenesis
energy homeostasis
binds to PPAR response elements (PPREs)
fatty acid storage
|
|
gptkbp:target
|
gptkb:thiazolidinediones
|
|
gptkbp:UniProtID
|
P37231
|
|
gptkbp:bfsParent
|
gptkb:chromosome_3p25
gptkb:Peroxisome_proliferator-activated_receptor
gptkb:familial_partial_lipodystrophy
|
|
gptkbp:bfsLayer
|
7
|