Peroxisome proliferator-activated receptor gamma

URI: https://gptkb.org/entity/Peroxisome_proliferator-activated_receptor_gamma
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
nuclear receptor
gptkbp:abbreviation PPARĪ³
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:biologicalProcess DNA binding
transcription factor activity
gptkbp:cellularComponent gptkb:nucleus
gptkbp:discoveredBy gptkb:Issemann_and_Green
gptkbp:discoveredIn 1990
gptkbp:encodedBy PPARG gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000132170
5468
gptkbp:expressedIn adipose tissue
colon
macrophages
immune cells
gptkbp:formsComplexWith retinoid X receptor
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of glucose metabolism
regulation of lipid metabolism
regulation of adipogenesis
gptkbp:GO GO:0003707
gptkbp:HGNC_ID 9236
https://www.w3.org/2000/01/rdf-schema#label Peroxisome proliferator-activated receptor gamma
gptkbp:ligand gptkb:thiazolidinediones
prostaglandins
fatty acids
gptkbp:locatedOnChromosome gptkb:chromosome_3p25
gptkbp:memberOf nuclear hormone receptor superfamily
gptkbp:OMIM 601487
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 3CS8
gptkbp:regulates cell differentiation
gene expression
inflammation
insulin sensitivity
gptkbp:role gptkb:cancer
gptkb:type_2_diabetes
obesity
atherosclerosis
gptkbp:target gptkb:pioglitazone
gptkb:rosiglitazone
antidiabetic drugs
gptkbp:UniProtID P37231
gptkbp:bfsParent gptkb:6MBT
gptkbp:bfsLayer 7