nuclear hormone receptor family
GPTKB entity
Statements (45)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
nuclear receptor family
|
| gptkbp:binds |
thyroid hormones
hormones vitamin D steroids retinoic acid |
| gptkbp:class |
orphan nuclear receptors
Class I nuclear receptors Class II nuclear receptors |
| gptkbp:contains |
DNA-binding domain
ligand-binding domain |
| gptkbp:database |
Gene Ontology: GO:0003707
InterPro: IPR001723 Pfam: PF00104 UniProtKB family: Nuclear hormone receptor |
| gptkbp:discoveredBy |
gptkb:Elwood_V._Jensen
|
| gptkbp:function |
regulation of gene expression
transcription factor activity |
| https://www.w3.org/2000/01/rdf-schema#label |
nuclear hormone receptor family
|
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:mechanismOfAction |
dimerization
binding to hormone response elements (HREs) ligand-dependent transcriptional regulation |
| gptkbp:member |
gptkb:peroxisome_proliferator-activated_receptor_(PPAR)
gptkb:androgen_receptor gptkb:farnesoid_X_receptor_(FXR) gptkb:liver_X_receptor_(LXR) thyroid hormone receptor estrogen receptor glucocorticoid receptor progesterone receptor mineralocorticoid receptor vitamin D receptor orphan nuclear receptor retinoic acid receptor |
| gptkbp:relatedTo |
gptkb:pharmacy
development cancer biology reproduction metabolism regulation endocrine signaling |
| gptkbp:bfsParent |
gptkb:LXRα
|
| gptkbp:bfsLayer |
7
|