Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:PGC-1α
LARSF3 PPAR-gamma coactivator 1-alpha PPARGC1 |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:type_2_diabetes
obesity neurodegenerative diseases |
| gptkbp:discoveredBy |
Bruce M. Spiegelman
|
| gptkbp:discoveredIn |
1998
|
| gptkbp:encodes |
PGC-1α protein
|
| gptkbp:Entrez_Gene_ID |
10891
ENSG00000109819 |
| gptkbp:expressedIn |
gptkb:brown_adipose_tissue
gptkb:skeletal_muscle brain heart liver |
| gptkbp:fullName |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
|
| gptkbp:function |
regulation of glucose metabolism
regulation of fatty acid oxidation coactivator of nuclear receptors regulation of adaptive thermogenesis regulation of genes involved in energy metabolism regulation of mitochondrial biogenesis |
| gptkbp:HGNC_ID |
9237
|
| https://www.w3.org/2000/01/rdf-schema#label |
PPARGC1A
|
| gptkbp:interactsWith |
gptkb:FOXO1
gptkb:CREB gptkb:MEF2C PPARγ ERRα |
| gptkbp:length |
798 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_4
4p15.1 |
| gptkbp:molecularWeight |
91 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:diabetes_mellitus
neurodegeneration |
| gptkbp:OMIM |
604517
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Ppargc1a
|
| gptkbp:phosphorylates |
regulated by AMPK
regulated by p38 MAPK |
| gptkbp:regulates |
gptkb:TFAM
inhibited by insulin PPARγ ERRα NRF1 NRF2 activated by cold exposure activated by exercise activated by fasting |
| gptkbp:UniProtID |
Q9UBK2
|
| gptkbp:bfsParent |
gptkb:PGC-1α
|
| gptkbp:bfsLayer |
7
|