Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:associated_with |
gptkb:smartphone
|
| gptkbp:discovered_by |
gptkb:Sir_John_Gurdon
|
| gptkbp:established |
differentiation
|
| gptkbp:function |
regulates pluripotency
|
| gptkbp:has_category |
Oct3/4
|
| https://www.w3.org/2000/01/rdf-schema#label |
Oct4
|
| gptkbp:interacts_with |
SO X2
|
| gptkbp:is_aimed_at |
gptkb:CRISPR_technology
|
| gptkbp:is_associated_with |
transcriptional activation
epigenetic modifications cellular reprogramming gene regulatory networks cellular reprogramming efficiency |
| gptkbp:is_essential_for |
stem cell maintenance
|
| gptkbp:is_involved_in |
gptkb:embryonic_development
cell cycle regulation cellular homeostasis cellular differentiation tissue regeneration organogenesis reprogramming somatic cells cell fate decisions cellular responses to stress cellular signaling. cellular plasticity embryonic stem cell self-renewal germline development |
| gptkbp:is_linked_to |
tumorigenesis
cellular aging metastasis epigenetic regulation cancer stem cells |
| gptkbp:is_part_of |
stem cell biology
developmental biology cellular signaling pathways transcriptional regulatory network stem cell niche pluripotency network |
| gptkbp:is_represented_in |
cancer cells
adult stem cells induced pluripotent stem cells somatic cells germ cells embryonic stem cells neural stem cells pluripotent stem cells fertilized eggs early embryogenesis early embryos |
| gptkbp:is_studied_in |
regenerative medicine
|
| gptkbp:location |
gptkb:physicist
|
| gptkbp:promoter |
PO U5 F1
|
| gptkbp:regulates |
gptkb:Nanog
gene expression transcription factors signaling pathways extracellular signals |
| gptkbp:requires |
blastocyst formation
|
| gptkbp:role |
cell differentiation
|
| gptkbp:targets |
micro RN As
|
| gptkbp:bfsParent |
gptkb:Yamanaka_factors
|
| gptkbp:bfsLayer |
4
|