Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:alternativeName |
gptkb:Oct3/4
gptkb:POU5F1 gptkb:POU_domain,_class_5,_transcription_factor_1 Oct-3 Oct-3/4 |
| gptkbp:binds |
octamer motif (ATGCAAAT)
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodedBy |
gptkb:POU5F1_gene
|
| gptkbp:expressedIn |
gptkb:germ_cells
embryonic stem cells |
| gptkbp:foundIn |
humans
mammals |
| gptkbp:function |
maintenance of stem cell self-renewal
regulation of pluripotency |
| gptkbp:HGNC_ID |
9221
|
| https://www.w3.org/2000/01/rdf-schema#label |
Oct4
|
| gptkbp:interactsWith |
gptkb:Klf4
gptkb:Sox2 gptkb:c-Myc gptkb:Nanog |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_6p21.31
|
| gptkbp:memberOf |
gptkb:POU_family
|
| gptkbp:molecularWeight |
38 kDa
|
| gptkbp:OMIM |
164177
|
| gptkbp:regulates |
gene expression
|
| gptkbp:requires |
early embryonic development
|
| gptkbp:structure |
contains POU-specific and POU-homeodomain
|
| gptkbp:UniProtID |
gptkb:Q01860
|
| gptkbp:usedIn |
induced pluripotent stem cell generation
|
| gptkbp:bfsParent |
gptkb:Klf4
gptkb:Sox2 |
| gptkbp:bfsLayer |
6
|