|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:POU_domain,_class_5,_transcription_factor_1
Oct-4
Oct-3
Octamer-binding transcription factor 4
|
|
gptkbp:biologicalProcess
|
DNA binding
transcriptional regulation
GO:0019827 (stem cell maintenance)
GO:0048863 (stem cell differentiation)
|
|
gptkbp:discoveredBy
|
gptkb:Hans_R._Schöler
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:domain
|
gptkb:POU-homeodomain
gptkb:POU-specific_domain
|
|
gptkbp:encodedBy
|
gptkb:POU5F1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5460
|
|
gptkbp:expressedIn
|
gptkb:germ_cells
embryonic stem cells
|
|
gptkbp:familyMember
|
gptkb:POU_family
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
maintenance of stem cell self-renewal
regulation of pluripotency
GO:0003700 (DNA-binding transcription factor activity)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OCT4 protein
|
|
gptkbp:interactsWith
|
gptkb:NANOG_protein
gptkb:SOX2_protein
|
|
gptkbp:length
|
360 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6p21.31
|
|
gptkbp:location
|
gptkb:nucleus
GO:0005634 (nucleus)
|
|
gptkbp:molecularWeight
|
38 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3JUG
3L1P
6HT5
|
|
gptkbp:regulates
|
gptkb:FGF4_gene
gptkb:SOX2_gene
gptkb:NANOG_gene
|
|
gptkbp:significance
|
marker for pluripotency
implicated in germ cell tumors
used in stem cell research
|
|
gptkbp:structure
|
contains POU-specific and POU-homeodomain regions
|
|
gptkbp:UniProtID
|
gptkb:Q01860
|
|
gptkbp:usedAs
|
immunohistochemical marker
|
|
gptkbp:usedIn
|
cell reprogramming
induced pluripotent stem cell generation
|
|
gptkbp:bfsParent
|
gptkb:POU5F1_gene
|
|
gptkbp:bfsLayer
|
7
|