|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:EZF
gptkb:GKLF
|
|
gptkbp:associatedWith
|
gptkb:cancer
epithelial-mesenchymal transition
|
|
gptkbp:component
|
gptkb:Yamanaka_factors
|
|
gptkbp:encodedBy
|
gptkb:KLF4_gene
|
|
gptkbp:Entrez_Gene_ID
|
9314
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
cornea
stem cells
intestine
epithelial tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KLF4 protein
|
|
gptkbp:interactsWith
|
gptkb:p53_protein
gptkb:beta-catenin
|
|
gptkbp:length
|
513 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
9q31
|
|
gptkbp:memberOf
|
gptkb:Kruppel-like_factor_family
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
602253
|
|
gptkbp:PDB
|
gptkb:2WBU
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
angiogenesis
cell migration
inflammation
DNA damage response
tumor suppression
cell adhesion
cell cycle arrest
oncogenesis
stem cell pluripotency
epithelial cell homeostasis
reprogramming of somatic cells
transcription of E-cadherin
transcription of Nanog
transcription of Oct4
transcription of p21
|
|
gptkbp:structure
|
zinc finger domains
|
|
gptkbp:UniProtID
|
O43474
|
|
gptkbp:usedIn
|
induced pluripotent stem cell generation
|
|
gptkbp:bfsParent
|
gptkb:POU5F1_gene
|
|
gptkbp:bfsLayer
|
7
|