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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PLCE
PLC-epsilon
NCALD
PLC1
|
|
gptkbp:alternativeName
|
gptkb:PLC-epsilon-1
gptkb:phospholipase_C,_epsilon_1
|
|
gptkbp:associatedWith
|
gptkb:nephrotic_syndrome_type_3
gastric cancer
esophageal squamous cell carcinoma
|
|
gptkbp:biologicalProcess
|
angiogenesis
regulation of cell growth
calcium ion binding
GTPase activator activity
phosphoinositide-mediated signaling
phosphoric diester hydrolase activity
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:domain
|
gptkb:PH_domain
gptkb:EF-hand_domain
C2 domain
CDC25 homology domain
Ras-associating domain
|
|
gptkbp:encodes
|
phospholipase C epsilon-1
|
|
gptkbp:Entrez_Gene_ID
|
51196
ENSG00000133056
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
|
|
gptkbp:function
|
signal transduction
hydrolyzes phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:9066
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCE1 gene
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q23.33
|
|
gptkbp:mutationAssociatedWith
|
gptkb:steroid-resistant_nephrotic_syndrome
|
|
gptkbp:OMIM
|
608414
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Plce1
|
|
gptkbp:proteinFamily
|
gptkb:phospholipase_C_family
|
|
gptkbp:regulates
|
gptkb:MAPK_signaling_pathway
gptkb:Ras_signaling_pathway
calcium signaling pathway
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
Q9P212
|
|
gptkbp:bfsParent
|
gptkb:PLCĪµ
|
|
gptkbp:bfsLayer
|
7
|