|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:PIM
gptkb:Proto-oncogene_serine/threonine-protein_kinase_Pim-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
hematological malignancies
|
|
gptkbp:biologicalProcess
|
serine/threonine kinase activity
|
|
gptkbp:clinicalTrialPhase
|
NCT01489722
|
|
gptkbp:discoveredBy
|
gptkb:Anton_Berns
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:PIM1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5292
ENSG00000137193
|
|
gptkbp:expressedIn
|
heart
liver
prostate tissue
hematopoietic tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:hasIsoform
|
PIM1-1
PIM1-2
|
|
gptkbp:hasMIMNumber
|
164960
|
|
gptkbp:hasRefSeqID
|
NP_002609.2
|
|
gptkbp:HGNC_ID
|
8986
|
|
gptkbp:inhibitedBy
|
gptkb:AZD1208
gptkb:SGI-1776
CX-6258
LGH447
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
cell cycle regulation
|
|
gptkbp:isOncogene
|
true
|
|
gptkbp:length
|
313 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:OMIM
|
164960
|
|
gptkbp:PDB
|
2C3I
1YHS
|
|
gptkbp:phosphorylates
|
gptkb:c-Myc
gptkb:BAD_protein
p21Cip1/WAF1
|
|
gptkbp:regulates
|
gptkb:translator
cell survival
transcription
|
|
gptkbp:structure
|
gptkb:monomer
|
|
gptkbp:target
|
small molecule inhibitors
|
|
gptkbp:UniProtID
|
P11309
|
|
gptkbp:bfsParent
|
gptkb:PIM_1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIM1 kinase
|