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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alias
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gptkb:PIM
proto-oncogene serine/threonine-protein kinase Pim-1
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gptkbp:associatedWith
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cell proliferation
prostate cancer
apoptosis regulation
hematological malignancies
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gptkbp:biologicalProcess
|
apoptosis
cell proliferation
cell survival
signal transduction
protein serine/threonine kinase activity
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gptkbp:cellularComponent
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gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:clinicalTrialPhase
|
NCT01239108
NCT01588548
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gptkbp:discoveredIn
|
1986
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gptkbp:encodes
|
PIM1 protein
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gptkbp:Entrez_Gene_ID
|
5292
ENSG00000137193
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gptkbp:expressedIn
|
bone marrow
lymphoid tissues
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gptkbp:function
|
serine/threonine kinase activity
|
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gptkbp:HGNC_ID
|
8986
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIM1 gene
|
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gptkbp:inhibitedBy
|
gptkb:AZD1208
gptkb:SGI-1776
CX-6258
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
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gptkbp:mutationAssociatedWith
|
leukemia
|
|
gptkbp:OMIM
|
164380
|
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologInMouse
|
Pim1
|
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gptkbp:phosphorylates
|
gptkb:p21_protein
gptkb:c-Myc_protein
gptkb:BAD_protein
gptkb:Histone_H3
RUNX3 protein
CDC25A protein
FOXO3a protein
HP1gamma protein
eIF4B protein
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gptkbp:product
|
gptkb:PIM1_kinase
|
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gptkbp:proteinFamily
|
gptkb:PIM_kinase_family
|
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gptkbp:regulates
|
apoptosis
cell cycle
regulated by JAK/STAT pathway
transcriptionally regulated by cytokines
|
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gptkbp:UniProtID
|
P11309
|
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gptkbp:bfsParent
|
gptkb:PIM_1
|
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gptkbp:bfsLayer
|
7
|