|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
gptkb:PIK3CA
|
|
gptkbp:biologicalProcess
|
kinase activity
|
|
gptkbp:component
|
gptkb:protein
|
|
gptkbp:discoveredBy
|
gptkb:Lewis_Cantley
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:domain
|
gptkb:PI3K/PI4K_domain
kinase domain
C2 domain
helical domain
|
|
gptkbp:encodedBy
|
gptkb:PIK3CA_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.153
|
|
gptkbp:formsComplexWith
|
p85 regulatory subunit
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3-kinase p110-alpha
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:length
|
1068
|
|
gptkbp:locatedOnChromosome
|
3q26.32
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylates
|
phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:productOfReaction
|
gptkb:phosphatidylinositol_3,4,5-trisphosphate
|
|
gptkbp:target
|
gptkb:alpelisib
gptkb:BYL719
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
|
gptkbp:bfsParent
|
gptkb:PIK3CA_(p110α)
|
|
gptkbp:bfsLayer
|
6
|