Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:PIK3CA
|
| gptkbp:component |
gptkb:phosphoinositide_3-kinase_(PI3K)_class_IA
|
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
|
| gptkbp:enzymeClassification |
gptkb:EC_2.7.1.153
|
| gptkbp:function |
catalyzes phosphorylation of phosphatidylinositol lipids
|
| gptkbp:interactsWith |
p85 regulatory subunit
|
| gptkbp:involvedIn |
gptkb:PI3K/AKT_signaling_pathway
|
| gptkbp:location |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:molecularWeight |
~110 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:endometrial_cancer colorectal cancer |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:structure |
contains C2 domain
contains kinase domain contains helical domain |
| gptkbp:target |
PI3K inhibitors
|
| gptkbp:bfsParent |
gptkb:PI3K_alpha
|
| gptkbp:bfsLayer |
8
|
| http://www.w3.org/2000/01/rdf-schema#label |
p110α catalytic subunit
|