phosphoinositide 3-kinase alpha
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alternativeName |
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
PI3Kα |
| gptkbp:associatedWith |
gptkb:cancer
colorectal cancer |
| gptkbp:catalyzes |
phosphorylation of phosphatidylinositol-4,5-bisphosphate
|
| gptkbp:EC_number |
2.7.1.153
|
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| https://www.w3.org/2000/01/rdf-schema#label |
phosphoinositide 3-kinase alpha
|
| gptkbp:involvedIn |
gptkb:PI3K/AKT_signaling_pathway
|
| gptkbp:location |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:mutationAssociatedWith |
E545K
H1047R |
| gptkbp:product |
phosphatidylinositol-3,4,5-trisphosphate
|
| gptkbp:regulates |
cell proliferation
cell survival metabolism cell growth |
| gptkbp:subunit |
gptkb:p110α
p85 regulatory subunit |
| gptkbp:target |
gptkb:alpelisib
PI3K inhibitors |
| gptkbp:UniProtID |
gptkb:P42336
|
| gptkbp:bfsParent |
gptkb:PI3K_alpha
|
| gptkbp:bfsLayer |
6
|