|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_delta_isoform
gptkb:PIK3CD_protein
|
|
gptkbp:associatedWith
|
gptkb:leukemia
chronic lymphocytic leukemia
|
|
gptkbp:biologicalProcess
|
signal transduction
regulation of apoptosis
regulation of cell proliferation
T cell activation
kinase activity
ATP binding
B cell development
|
|
gptkbp:catalyzes
|
phosphorylation of phosphatidylinositol (4,5)-bisphosphate
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:encodedBy
|
gptkb:PIK3CD_gene
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:hasCatalyticSubunit
|
gptkb:p110δ
|
|
gptkbp:hasRegulatorySubunit
|
p50
p55
p85
|
|
gptkbp:involvedIn
|
gptkb:immune_response
cell signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.22
|
|
gptkbp:memberOf
|
gptkb:phosphoinositide_3-kinase_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:immunodeficiency
activated PI3K-delta syndrome (APDS)
|
|
gptkbp:overexpressedIn
|
gptkb:leukocytes
|
|
gptkbp:produces
|
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
|
|
gptkbp:subunit
|
gptkb:class_IA_PI3K_complex
|
|
gptkbp:target
|
gptkb:copanlisib
gptkb:duvelisib
gptkb:idelalisib
gptkb:umbralisib
|
|
gptkbp:UniProtID
|
O00329
|
|
gptkbp:bfsParent
|
gptkb:PIK3CD
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K-delta
|