|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:Mitochondrial_transcription_factor_A
gptkb:mtTFA
|
|
gptkbp:discoveredBy
|
T. Larsson et al.
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000197461
7019
|
|
gptkbp:expressedIn
|
all human tissues
|
|
gptkbp:fullName
|
gptkb:Transcription_Factor_A,_Mitochondrial
|
|
gptkbp:function
|
mitochondrial DNA maintenance
mitochondrial DNA packaging
mitochondrial transcription factor
|
|
gptkbp:gene
|
gptkb:TFAM
|
|
gptkbp:GO
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003677 (DNA binding)
GO:0005739 (mitochondrion)
|
|
gptkbp:HGNC_ID
|
11744
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TFAM
|
|
gptkbp:interactsWith
|
gptkb:mitochondrial_DNA
gptkb:POLRMT
gptkb:TFB1M
gptkb:TFB2M
|
|
gptkbp:locatedOnChromosome
|
10q21.1
|
|
gptkbp:location
|
mitochondria
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:mutationAssociatedWith
|
mitochondrial diseases
|
|
gptkbp:OMIM
|
600438
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus_TFAM
gptkb:Rattus_norvegicus_TFAM
|
|
gptkbp:PDB
|
gptkb:3TMM
|
|
gptkbp:phosphorylates
|
gptkb:Serine_177
gptkb:Serine_55
gptkb:Serine_61
|
|
gptkbp:regulates
|
regulated by NRF1
regulated by NRF2
regulated by PGC-1α
|
|
gptkbp:requires
|
mitochondrial biogenesis
mtDNA replication
mtDNA transcription
|
|
gptkbp:role
|
initiates mitochondrial transcription
regulates mitochondrial DNA copy number
stabilizes mitochondrial DNA
|
|
gptkbp:sequence
|
246 amino acids
|
|
gptkbp:significance
|
decreased levels linked to neurodegenerative diseases
altered expression in cancer
implicated in aging
|
|
gptkbp:structure
|
contains two HMG-box domains
|
|
gptkbp:subcellularLocation
|
mitochondrial matrix
|
|
gptkbp:UniProtID
|
Q00059
|
|
gptkbp:bfsParent
|
gptkb:Taipei_Fine_Arts_Museum
|
|
gptkbp:bfsLayer
|
5
|