Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
programmed cell death
|
| gptkbp:code |
gptkb:PD-1_protein
|
| gptkbp:discovered_by |
gptkb:1992
|
| gptkbp:function |
regulation of immune system
|
| gptkbp:genetic_studies |
autoimmune diseases
|
| gptkbp:has_role |
T cell exhaustion
|
| https://www.w3.org/2000/01/rdf-schema#label |
PDCD1
|
| gptkbp:interacts_with |
gptkb:PD-L1
|
| gptkbp:involved_in |
immune response
|
| gptkbp:is_associated_with |
gptkb:Oncology
therapeutic efficacy solid tumors tumor progression chronic infections HIV infection metastatic disease chronic inflammatory conditions |
| gptkbp:is_expressed_in |
gptkb:tumor_infiltrating_lymphocytes
gptkb:T_cells gptkb:Cell B cells tumor microenvironment myeloid cells plasma cells dendritic cells natural killer cells monocytes effector T cells activated T cells circulating immune cells |
| gptkbp:is_involved_in |
immune tolerance
cancer progression autoimmunity cytokine production T cell differentiation immune response modulation immune checkpoint blockade tumor immune evasion tumor microenvironment modulation immune surveillance immune checkpoint regulation immune system activation immune checkpoint therapy immune system homeostasis immune cell interactions cancer treatment response Treg cell function T cell activation regulation T cell homeostasis immune checkpoint signaling immune escape mechanisms negative regulation of T cell activation |
| gptkbp:is_linked_to |
therapeutic strategies
inflammatory diseases therapeutic resistance |
| gptkbp:is_part_of |
immune checkpoint pathway
|
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
immune checkpoint inhibitors
|
| gptkbp:located_in |
human chromosome 2
|
| gptkbp:orthologs |
other species
|
| gptkbp:related_to |
cancer immunotherapy
|
| gptkbp:targets |
monoclonal antibodies
|
| gptkbp:bfsParent |
gptkb:PD-1
|
| gptkbp:bfsLayer |
6
|