Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
poor prognosis
immune evasion |
| gptkbp:can_detect |
blood samples
|
| gptkbp:code |
gptkb:CD274_gene
|
| gptkbp:function |
inhibits T-cell activation
|
| gptkbp:has_role |
autoimmune diseases
|
| https://www.w3.org/2000/01/rdf-schema#label |
PD-L1
|
| gptkbp:influences |
tumor microenvironment
|
| gptkbp:initiated_by |
monoclonal antibodies
|
| gptkbp:interacts_with |
gptkb:PD-1
|
| gptkbp:involved_in |
cancer progression
|
| gptkbp:is_associated_with |
response to therapy
|
| gptkbp:is_expressed_in |
gptkb:disease
gptkb:hepatocellular_carcinoma gptkb:head_and_neck_squamous_cell_carcinoma gptkb:Oncology ovarian cancer macrophages dendritic cells tumor cells esophageal cancer |
| gptkbp:is_found_in |
human tissues
|
| gptkbp:is_involved_in |
regulation of immune response
immune tolerance adaptive immunity transplant rejection innate immunity chronic infections immune system modulation immune checkpoint blockade immune response regulation tumor microenvironment modulation cytokine signaling T-cell regulation T-cell exhaustion cancer immunoediting cancer therapy resistance lymphocyte infiltration cancer cell immune evasion cancer cell survival tumor-associated macrophage activation tumor antigen presentation immune checkpoint signaling tumor growth promotion tumor immune surveillance |
| gptkbp:is_linked_to |
viral infections
tumor immune escape |
| gptkbp:is_part_of |
immune checkpoint pathway
|
| gptkbp:is_regulated_by |
cytokines
|
| gptkbp:is_studied_for |
therapeutic applications
|
| gptkbp:is_targeted_at |
gptkb:pembrolizumab
gptkb:nivolumab cancer immunotherapy immune checkpoint inhibitors |
| gptkbp:is_upregulated_in |
certain cancers
|
| gptkbp:measures |
immunohistochemistry
|
| gptkbp:bfsParent |
gptkb:Tecentriq
gptkb:Imfinzi |
| gptkbp:bfsLayer |
5
|