|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:DJ-1
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
protein folding
response to oxidative stress
oxidoreductase activity
chaperone binding
protein deglycase activity
cellular response to toxic substances
|
|
gptkbp:discoveredBy
|
gptkb:Nagakubo_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:PARK7_gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.5.1.124
|
|
gptkbp:function
|
acts as a redox-sensitive chaperone
deglycase activity
protects cells against oxidative stress
|
|
gptkbp:GOID
|
gptkb:GO:0005739
GO:0005634
GO:0005829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PARK7 protein
|
|
gptkbp:interactsWith
|
gptkb:alpha-synuclein
gptkb:parkin_protein
gptkb:PINK1_protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36.23
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
20 kDa
|
|
gptkbp:mutationAssociatedWith
|
linked to autosomal recessive early-onset Parkinson's disease
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila melanogaster DJ-1beta
Mus musculus DJ-1
|
|
gptkbp:partOf
|
gptkb:DJ-1/ThiJ/PfpI_superfamily
|
|
gptkbp:PDB
|
1P5F
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
|
|
gptkbp:regulates
|
apoptosis
transcription
mitochondrial function
|
|
gptkbp:sequence
|
189 amino acids
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
Q99497
|
|
gptkbp:bfsParent
|
gptkb:DJ-1_gene
|
|
gptkbp:bfsLayer
|
8
|