Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
gptkb:autosomal_recessive_juvenile_Parkinson's_disease
|
| gptkbp:discoveredBy |
gptkb:Japanese_research_group_led_by_Dr._Nobutaka_Hattori
|
| gptkbp:discoveredIn |
1998
|
| gptkbp:domain |
RING finger domain
Ubiquitin-like domain |
| gptkbp:encodedBy |
gptkb:PARK2_gene
|
| gptkbp:function |
E3 ubiquitin ligase
|
| https://www.w3.org/2000/01/rdf-schema#label |
parkin protein
|
| gptkbp:involvedIn |
ubiquitin-proteasome system
|
| gptkbp:locale |
gptkb:cytoplasm
mitochondria |
| gptkbp:locatedOnChromosome |
6q25.2-q27
|
| gptkbp:molecularWeight |
52 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:early-onset_Parkinson's_disease
|
| gptkbp:orthologIn |
gptkb:mouse
gptkb:Drosophila_melanogaster |
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:regulates |
mitophagy
|
| gptkbp:UniProtID |
O60260
|
| gptkbp:bfsParent |
gptkb:PARK2_gene
gptkb:PARK2 |
| gptkbp:bfsLayer |
7
|