|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:BRPK
gptkb:PTEN_induced_putative_kinase_1
PARK6 protein
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
neurodegeneration
neurodegenerative disorders
autosomal recessive inheritance
|
|
gptkbp:discoveredBy
|
gptkb:Valina_L._Dawson
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:encodedBy
|
gptkb:PINK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
65018
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.1
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
|
|
gptkbp:fullName
|
gptkb:PTEN-induced_putative_kinase_1
|
|
gptkbp:function
|
serine/threonine kinase activity
mitochondrial quality control
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PINK1 protein
|
|
gptkbp:interactsWith
|
gptkb:TOM_complex
gptkb:Hsp90
gptkb:DJ-1_protein
gptkb:Parkin_protein
|
|
gptkbp:involvedIn
|
gptkb:Parkinson's_disease_pathway
mitophagy
|
|
gptkbp:locale
|
mitochondria
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:early-onset_Parkinson's_disease
missense mutation
nonsense mutation
frameshift mutation
splice site mutation
|
|
gptkbp:OMIM
|
608309
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:phosphorylates
|
gptkb:Parkin_protein
|
|
gptkbp:postTranslationalModification
|
autophosphorylation
ubiquitination
|
|
gptkbp:regulates
|
mitochondrial dynamics
mitochondrial fission
mitochondrial fusion
|
|
gptkbp:structure
|
contains kinase domain
|
|
gptkbp:subcellularLocation
|
inner mitochondrial membrane
cytosol
outer mitochondrial membrane
|
|
gptkbp:UniProtID
|
gptkb:Q9BXM7
|
|
gptkbp:bfsParent
|
gptkb:PINK1_gene
|
|
gptkbp:bfsLayer
|
8
|