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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:Antigen_NY-CO-13
gptkb:Cellular_tumor_antigen_p53
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
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gptkbp:biologicalProcess
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DNA repair
Autophagy
Transcription regulation
Apoptosis
DNA-binding
Cell cycle arrest
Senescence
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gptkbp:disease_involvement
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gptkb:Li-Fraumeni_syndrome
Various cancers
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gptkbp:Entrez_Gene_ID
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gptkb:ENSP00000269305
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gptkbp:firstDescribed
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1979
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gptkbp:function
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Tumor suppressor
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gptkbp:gene
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gptkb:TP53
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gptkbp:GO_term
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gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
GO:0006915 (apoptotic process)
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gptkbp:heldBy
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DNA-binding protein
Transcription factor
Tumor suppressor protein
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gptkbp:HGNC_ID
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11998
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https://www.w3.org/2000/01/rdf-schema#label
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P17676
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gptkbp:locatedOnChromosome
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17p13.1
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gptkbp:molecularWeight
|
43.7 kDa
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gptkbp:OMIM
|
191170
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:PDB
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gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
5XVK
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gptkbp:postTranslationalModification
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Phosphorylation
Acetylation
Ubiquitination
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gptkbp:proteinFamily
|
gptkb:p53_family
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gptkbp:refersTo
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gptkb:Tumor_protein_p53_(human)
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gptkbp:RefSeq
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NP_000537.3
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gptkbp:sequence
|
393 amino acids
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gptkbp:subcellularLocation
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gptkb:Nucleus
gptkb:Cytoplasm
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gptkbp:subunit
|
Tetramer
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gptkbp:UniProt_reviewed
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Yes
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gptkbp:UniProtKB_entry
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gptkb:P17676
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gptkbp:bfsParent
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gptkb:CEBPB_gene
gptkb:P17676-3
gptkb:C/EBP_beta
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gptkbp:bfsLayer
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8
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