|
gptkbp:instanceOf
|
gptkb:UniProt_accession_number
|
|
gptkbp:alternativeName
|
gptkb:Antigen_NY-CO-13
gptkb:Cellular_tumor_antigen_p53
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
|
|
gptkbp:biologicalProcess
|
DNA repair
Autophagy
Transcription regulation
Apoptosis
DNA-binding
Cell cycle arrest
Senescence
|
|
gptkbp:disease_involvement
|
gptkb:Li-Fraumeni_syndrome
Various cancers
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSP00000269305
|
|
gptkbp:firstDescribed
|
1979
|
|
gptkbp:function
|
Tumor suppressor
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:GO_term
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
GO:0006915 (apoptotic process)
|
|
gptkbp:heldBy
|
gptkb:Transcription_factor
DNA-binding protein
Tumor suppressor protein
|
|
gptkbp:HGNC_ID
|
11998
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
5XVK
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Acetylation
Ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:p53_family
|
|
gptkbp:refersTo
|
gptkb:Tumor_protein_p53_(human)
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:sequence
|
393 amino acids
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cytoplasm
|
|
gptkbp:subunit
|
Tetramer
|
|
gptkbp:UniProt_reviewed
|
Yes
|
|
gptkbp:UniProtKB_entry
|
gptkb:P17676
|
|
gptkbp:bfsParent
|
gptkb:CEBPB_gene
gptkb:P17676-3
gptkb:C/EBP_beta
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P17676
|