|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ER
gptkb:NR3A1
|
|
gptkbp:associatedWith
|
gptkb:Endometrial_cancer
Osteoporosis
Breast cancer
|
|
gptkbp:biologicalProcess
|
regulation of transcription, DNA-templated
DNA-binding transcription factor activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
DNA-binding domain
Ligand-binding domain
|
|
gptkbp:Drug_target
|
Tamoxifen
Raloxifene
Fulvestrant
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000350283
|
|
gptkbp:family
|
Nuclear hormone receptor family
|
|
gptkbp:function
|
Transcription factor
Nuclear hormone receptor for estrogens
|
|
gptkbp:gene
|
gptkb:ESR1
|
|
gptkbp:hasIsoform
|
ER alpha 36
ER alpha 46
ER alpha 66
|
|
gptkbp:HGNC_ID
|
3467
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P04156
|
|
gptkbp:InterPro
|
IPR001292
IPR003074
|
|
gptkbp:KEGGID
|
hsa:2099
|
|
gptkbp:length
|
595 amino acids
|
|
gptkbp:ligand
|
Estrogen
|
|
gptkbp:locatedOnChromosome
|
6q25.1
chr6:151656691-152129619
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:OMIM
|
133430
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1A52
3ERT
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Ubiquitination
Sumoylation
|
|
gptkbp:protein_name
|
gptkb:Estrogen_receptor
|
|
gptkbp:proteinFamily
|
PF00104
PF02159
|
|
gptkbp:Reactome
|
R-HSA-8939211
|
|
gptkbp:RefSeq
|
NP_000116.2
|
|
gptkbp:reviewedBy
|
Yes
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cytoplasm
Plasma membrane
|
|
gptkbp:subfamily
|
gptkb:Steroid_hormone_receptors
|
|
gptkbp:UniGene
|
Hs.654654
|
|
gptkbp:UniProtID
|
gptkb:P04156
|
|
gptkbp:bfsParent
|
gptkb:PRNP
gptkb:prion_protein
gptkb:PRNB
gptkb:PrP_(prion_protein)
|
|
gptkbp:bfsLayer
|
8
|