|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CD230
PrP
|
|
gptkbp:associatedWith
|
gptkb:Creutzfeldt-Jakob_disease
gptkb:Gerstmann-Sträussler-Scheinker_syndrome
gptkb:fatal_familial_insomnia
kuru
prion diseases
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_B._Prusiner
|
|
gptkbp:encodedBy
|
gptkb:PRNP_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000171867
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
central nervous system
lymphoid tissue
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
cellular signaling
copper binding
|
|
gptkbp:gene
|
gptkb:PRNP
|
|
gptkbp:HGNC_ID
|
9443
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
prion protein
|
|
gptkbp:length
|
253 amino acids (human)
|
|
gptkbp:locatedOnChromosome
|
chromosome 20 (human)
|
|
gptkbp:location
|
gptkb:cell_membrane
neurons
|
|
gptkbp:misfoldedForm
|
PrPSc
|
|
gptkbp:MolecularWeight
|
27-35 kDa
|
|
gptkbp:mutationAssociatedWith
|
neurodegeneration
hereditary prion diseases
|
|
gptkbp:Nomenclature
|
UniProt:P04156
|
|
gptkbp:normalForm
|
PrPC
|
|
gptkbp:OMIM
|
176640
|
|
gptkbp:PDB
|
1AG2
1I4M
1QLX
1XYX
|
|
gptkbp:postTranslationalModification
|
gptkb:GPI-anchor
glycosylation
|
|
gptkbp:RefSeq
|
NM_000311
|
|
gptkbp:role
|
neurotoxicity
amyloid plaque formation
infectious agent in prion diseases
template for misfolding
|
|
gptkbp:structure
|
alpha-helical
|
|
gptkbp:UniProtID
|
gptkb:P04156
|
|
gptkbp:variant
|
bovine PrP
human PrP
murine PrP
ovine PrP
|
|
gptkbp:bfsParent
|
gptkb:kuru_prion_disease
gptkb:G127X
gptkb:Shadoo
|
|
gptkbp:bfsLayer
|
7
|