|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CD230
PrP
Prion protein
|
|
gptkbp:associatedWith
|
prion diseases
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_B._Prusiner
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:PRNP_gene
|
|
gptkbp:foundIn
|
mammals
|
|
gptkbp:function
|
unknown
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PrP (prion protein)
|
|
gptkbp:involves
|
gptkb:Kuru
gptkb:Creutzfeldt-Jakob_disease
gptkb:Bovine_spongiform_encephalopathy
gptkb:Gerstmann-Sträussler-Scheinker_syndrome
gptkb:Fatal_familial_insomnia
|
|
gptkbp:length
|
253 amino acids (human)
|
|
gptkbp:locatedOnChromosome
|
chromosome 20 (human)
|
|
gptkbp:location
|
gptkb:cell_membrane
central nervous system
neurons
|
|
gptkbp:misfoldedForm
|
PrPSc
|
|
gptkbp:mutationAssociatedWith
|
D178N
E200K
M129V
P102L
V210I
octapeptide repeat insertions
|
|
gptkbp:normalForm
|
PrPC
|
|
gptkbp:OMIM
|
176640
|
|
gptkbp:pathogenicForm
|
amyloid plaques
aggregates
|
|
gptkbp:postTranslationalModification
|
gptkb:GPI-anchor
glycosylation
|
|
gptkbp:relatedTo
|
neurodegeneration
protein misfolding
transmissible spongiform encephalopathies
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:transmission
|
hereditary
sporadic
infectious
|
|
gptkbp:UniProtID
|
gptkb:P04156
|
|
gptkbp:variant
|
gptkb:deer
gptkb:elk
gptkb:human
gptkb:livestock
gptkb:mouse
|
|
gptkbp:bfsParent
|
gptkb:3F2.1_(mouse)
|
|
gptkbp:bfsLayer
|
7
|