Statements (37)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
nuclear hormone receptors
|
| gptkbp:discoveredIn |
1960s
|
| gptkbp:domain |
DNA-binding domain
ligand-binding domain activation domain |
| gptkbp:example |
gptkb:androgen_receptor
estrogen receptor glucocorticoid receptor progesterone receptor mineralocorticoid receptor vitamin D receptor |
| gptkbp:foundIn |
vertebrates
some invertebrates |
| gptkbp:function |
regulate gene expression
bind steroid hormones |
| https://www.w3.org/2000/01/rdf-schema#label |
Steroid hormone receptors
|
| gptkbp:ligand |
gptkb:progesterone
gptkb:aldosterone gptkb:estradiol cortisol vitamin D testosterone |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:mechanismOfAction |
act as transcription factors
|
| gptkbp:memberOf |
nuclear receptor superfamily
|
| gptkbp:mutationAssociatedWith |
can cause hormone resistance syndromes
|
| gptkbp:regulates |
by coactivators
by corepressors by ligand binding by phosphorylation |
| gptkbp:significance |
target for cancer therapy
target for endocrine disorders |
| gptkbp:structure |
modular
|
| gptkbp:bfsParent |
gptkb:Nuclear_Hormone_Receptor
|
| gptkbp:bfsLayer |
8
|