|
gptkbp:instanceOf
|
gptkb:opioid
|
|
gptkbp:alsoKnownAs
|
gptkb:Demerol
pethidine
|
|
gptkbp:ATCCode
|
N02AB02
|
|
gptkbp:CASNumber
|
57-42-1
|
|
gptkbp:chemicalClass
|
gptkb:4-phenylpiperidine
|
|
gptkbp:contraindication
|
MAOI use
hypersensitivity
severe respiratory depression
|
|
gptkbp:developedBy
|
gptkb:IG_Farben
|
|
gptkbp:discoveredBy
|
gptkb:Otto_Eisleb
|
|
gptkbp:discoveredIn
|
1939
|
|
gptkbp:eliminationHalfLife
|
2.5-4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:firstSynthesized
|
1939
|
|
gptkbp:hasMolecularFormula
|
C15H21NO2
|
|
gptkbp:KEGGID
|
D08109
|
|
gptkbp:legalStatus
|
gptkb:Schedule_II_(US)
Prescription only (various countries)
|
|
gptkbp:mechanismOfAction
|
mu-opioid receptor agonist
|
|
gptkbp:meltingPoint
|
186-189°C (hydrochloride salt)
|
|
gptkbp:metabolism
|
liver
normeperidine
|
|
gptkbp:notRecommendedFor
|
elderly patients
chronic pain
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
4058
CHEMBL1531
DB00454
|
|
gptkbp:riskFactor
|
addiction
abuse
overdose
seizures (with high doses or renal impairment)
serotonin syndrome (with serotonergic drugs)
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
constipation
dizziness
drowsiness
respiratory depression
|
|
gptkbp:solubility
|
soluble in water (hydrochloride salt)
|
|
gptkbp:UNII
|
UY443GRB0G
|
|
gptkbp:usedFor
|
pain management
|
|
gptkbp:usedIn
|
preoperative sedation
obstetric analgesia
|
|
gptkbp:bfsParent
|
gptkb:Schedule_II
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Meperidine
|