|
gptkbp:instanceOf
|
gptkb:drug
antidiarrheal agent
|
|
gptkbp:abusePotential
|
low (at recommended doses)
|
|
gptkbp:affects
|
intestinal motility
|
|
gptkbp:approvalYear
|
1976
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
A07DA03
|
|
gptkbp:brand
|
gptkb:Imodium
Diamode
|
|
gptkbp:CASNumber
|
53179-11-6
|
|
gptkbp:chemicalClass
|
piperidine derivative
|
|
gptkbp:contraindication
|
ulcerative colitis
children under 2 years
bacterial enterocolitis
acute dysentery
|
|
gptkbp:discoveredBy
|
gptkb:Janssen_Pharmaceutica
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:doesNotCross
|
blood-brain barrier (significantly)
|
|
gptkbp:eliminationHalfLife
|
9–14 hours
|
|
gptkbp:excretion
|
feces
|
|
gptkbp:hasMolecularFormula
|
C29H33ClN2O2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Loperamide
|
|
gptkbp:legalStatus
|
OTC (over-the-counter) in many countries
prescription-only in some countries
|
|
gptkbp:mechanismOfAction
|
mu-opioid receptor agonist
|
|
gptkbp:MedlinePlusID
|
a682280
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:overdoseSymptoms
|
gptkb:arrhythmia
QT prolongation
CNS depression
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL656
3955
DB00836
|
|
gptkbp:routeOfAdministration
|
oral
chewable tablet
oral solution
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
constipation
drowsiness
|
|
gptkbp:UNII
|
6X9OC3H4II
|
|
gptkbp:usedFor
|
treatment of diarrhea
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Opioids
|
|
gptkbp:bfsLayer
|
7
|