|
gptkbp:instanceOf
|
gptkb:drug
antitussive
|
|
gptkbp:abusePotential
|
yes
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
R05DA09
|
|
gptkbp:brand
|
gptkb:Coricidin
gptkb:Delsym
gptkb:NyQuil
gptkb:Robitussin
gptkb:Vicks_44
|
|
gptkbp:CASNumber
|
125-71-3
|
|
gptkbp:category
|
NMDA receptor antagonist
antitussive agent
opioid
norepinephrine reuptake inhibitor
sigma receptor agonist
|
|
gptkbp:chemicalFormula
|
C18H25NO
|
|
gptkbp:contraindication
|
MAOI use
|
|
gptkbp:controlledSubstanceSchedule
|
gptkb:Australia
gptkb:Canada
gptkb:New_Zealand
gptkb:Sweden
|
|
gptkbp:discoveredIn
|
1953
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:SSRIs
CYP2D6 inhibitors
MAOIs
|
|
gptkbp:eliminationHalfLife
|
3-6 hours
|
|
gptkbp:firstSynthesized
|
gptkb:C._F._Boehringer_&_Söhne
|
|
gptkbp:foundInCombinationWith
|
gptkb:pseudoephedrine
acetaminophen
antihistamines
guaifenesin
|
|
gptkbp:hasEnantiomer
|
gptkb:levomethorphan
|
|
gptkbp:hasMetabolite
|
gptkb:dextrorphan
gptkb:3-hydroxymorphinan
gptkb:3-methoxymorphinan
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dextromethorphan
|
|
gptkbp:isomerOf
|
gptkb:levomethorphan
|
|
gptkbp:IUPACName
|
gptkb:(4aR,10aR)-3-methoxy-17-methylmorphinan
|
|
gptkbp:legalStatus
|
OTC (over-the-counter) in US
|
|
gptkbp:mainStreet
|
gptkb:DXM
skittles
robo
triple C
|
|
gptkbp:marketedAs
|
gptkb:Nuedexta_(with_quinidine)
|
|
gptkbp:mechanismOfAction
|
NMDA receptor antagonist
norepinephrine reuptake inhibitor
sigma-1 receptor agonist
|
|
gptkbp:metabolism
|
gptkb:CYP2D6
liver
|
|
gptkbp:molecularWeight
|
271.4 g/mol
|
|
gptkbp:notControlledSubstanceIn
|
gptkb:United_States
|
|
gptkbp:overdoseSymptoms
|
dissociation
respiratory depression
euphoria
ataxia
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescriptionStatus
|
OTC in US
Rx in some countries
|
|
gptkbp:PubChem_CID
|
5360696
|
|
gptkbp:relatedTo
|
gptkb:codeine
gptkb:morphine
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
confusion
nausea
vomiting
constipation
dizziness
drowsiness
hallucinations (at high doses)
|
|
gptkbp:toxicity
|
liver damage (with acetaminophen)
serotonin syndrome (with other serotonergic drugs)
|
|
gptkbp:UNII
|
7355X3RO96
|
|
gptkbp:usedAsRecreationalDrug
|
yes
|
|
gptkbp:usedFor
|
cough suppression
|
|
gptkbp:usedInTreatmentOf
|
pseudobulbar affect (with quinidine)
|
|
gptkbp:bfsParent
|
gptkb:Cough_syrup
|
|
gptkbp:bfsLayer
|
6
|