|
gptkbp:instanceOf
|
gptkb:G_protein-coupled_receptor
gptkb:opioid
|
|
gptkbp:alternativeName
|
gptkb:DOR
gptkb:OPRD1
|
|
gptkbp:binds
|
gptkb:enkephalins
gptkb:deltorphins
synthetic opioids
|
|
gptkbp:couplingType
|
gptkb:Gi/o_proteins
|
|
gptkbp:discoveredBy
|
1970s
|
|
gptkbp:effect
|
inhibits adenylyl cyclase
inhibits neurotransmitter release
reduces cAMP levels
|
|
gptkbp:encodedBy
|
gptkb:OPRD1_gene
|
|
gptkbp:enemyOf
|
gptkb:naloxone
gptkb:DPDPE
gptkb:SNC80
gptkb:deltorphin_II
gptkb:naltrindole
ARM390
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
peripheral tissues
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
gptkb:right
|
|
gptkbp:function
|
regulation of mood
modulation of pain
modulation of reward pathways
|
|
gptkbp:involvedIn
|
addiction
tolerance
respiratory depression (less than mu receptor)
|
|
gptkbp:locatedIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:locatedOnChromosome
|
chromosome 1p36.1
|
|
gptkbp:modulatedBy
|
dopamine release
GABA release
acetylcholine release
glutamate release
serotonin release
|
|
gptkbp:relatedTo
|
kappa opioid receptor
mu opioid receptor
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:targetOfDrug
|
antidepressants
anxiolytics
analgesics
|
|
gptkbp:UniProtID
|
gptkb:P41143
|
|
gptkbp:bfsParent
|
gptkb:Opioids
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Delta opioid receptor
|