|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:antidote
|
gptkb:Flumazenil
|
|
gptkbp:broadcastOn
|
Schedule IV (US)
|
|
gptkbp:canCross
|
gptkb:Blood-brain_barrier
gptkb:Placenta
|
|
gptkbp:cause
|
Tolerance
Withdrawal symptoms
|
|
gptkbp:contraindication
|
gptkb:Acute_narrow-angle_glaucoma
gptkb:Myasthenia_gravis
Severe respiratory insufficiency
Sleep apnea syndrome
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:example
|
gptkb:Alprazolam
gptkb:Clonazepam
gptkb:Diazepam
gptkb:Lorazepam
gptkb:Chlordiazepoxide
gptkb:Midazolam
gptkb:Temazepam
|
|
gptkbp:excretion
|
gptkb:Kidneys
|
|
gptkbp:firstMarketedBy
|
gptkb:Hoffmann-La_Roche
|
|
gptkbp:form
|
gptkb:tablet
gptkb:Injection
Oral solution
Rectal gel
|
|
gptkbp:foundIn
|
gptkb:Essential_Medicines_List_(WHO)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Benzodiazepines
|
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:Antidepressants
gptkb:Barbiturates
gptkb:Opioids
Antihistamines
Antipsychotics
|
|
gptkbp:legalStatus
|
Prescription only
|
|
gptkbp:marketedAs
|
1960
|
|
gptkbp:mechanismOfAction
|
Enhance GABA-A receptor activity
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:overdoseSymptoms
|
Increased with alcohol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:riskFactor
|
Addiction
Falls in elderly
Memory impairment
Paradoxical reactions
|
|
gptkbp:sideEffect
|
Dizziness
Cognitive impairment
Dependence
Drowsiness
Respiratory depression
|
|
gptkbp:usedFor
|
gptkb:Insomnia
Anxiety disorders
Alcohol withdrawal
Muscle spasms
Seizure disorders
|
|
gptkbp:bfsParent
|
gptkb:Insomnia
|
|
gptkbp:bfsLayer
|
5
|