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gptkbp:instanceOf
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Transcription factor
Protein family
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gptkbp:abbreviation
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gptkb:NR
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gptkbp:activatedBy
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Ligands
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gptkbp:binds
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gptkb:gene
Hormones
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gptkbp:discoveredBy
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gptkb:Elwood_V._Jensen
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gptkbp:domain
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DNA-binding domain
Transactivation domain
Ligand-binding domain
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gptkbp:example
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gptkb:Androgen_receptor
gptkb:Estrogen_receptor
gptkb:Glucocorticoid_receptor
gptkb:Retinoic_acid_receptor
gptkb:Thyroid_hormone_receptor
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gptkbp:firstDescribed
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1960s
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gptkbp:foundIn
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gptkb:Vertebrates
gptkb:Plants
Invertebrates
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gptkbp:function
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Regulate gene expression
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https://www.w3.org/2000/01/rdf-schema#label
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Nuclear Hormone Receptor
|
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gptkbp:involves
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Development
Metabolism
Reproduction
Homeostasis
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gptkbp:location
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Cell nucleus
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gptkbp:mechanismOfAction
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Coactivator recruitment
Corepressor recruitment
Dimerization
Ligand-dependent transcriptional regulation
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gptkbp:proteinFamily
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gptkb:NR2
gptkb:NR4
gptkb:NR3
gptkb:NR5
gptkb:NR0
NR1
NR6
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gptkbp:regulates
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Target gene transcription
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gptkbp:relatedTo
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gptkb:Signal_transduction
gptkb:Orphan_receptors
gptkb:Steroid_hormone_receptors
Gene regulation
Endocrine signaling
Metabolic regulation
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gptkbp:structure
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Modular
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gptkbp:superfamily
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gptkb:Nuclear_receptor_superfamily
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gptkbp:target
|
Pharmaceutical drugs
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gptkbp:bfsParent
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gptkb:NHR
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gptkbp:bfsLayer
|
7
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