Mitogen-activated protein kinase family
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
cytokines
mitogens stress signals |
| gptkbp:alsoKnownAs |
gptkb:MAPK_family
|
| gptkbp:contains |
gptkb:JNK
gptkb:p38_MAPK gptkb:ERK gptkb:ERK5 |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:enzymeClassification |
gptkb:EC_2.7.11.24
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
signal transduction
phosphorylation of target proteins |
| gptkbp:GO_term |
GO:0000165
|
| gptkbp:hasBiologicalActivity |
protein serine/threonine kinase activity
protein tyrosine kinase activity |
| https://www.w3.org/2000/01/rdf-schema#label |
Mitogen-activated protein kinase family
|
| gptkbp:involvedIn |
gptkb:MAPK/ERK_pathway
gptkb:MAPK/JNK_pathway gptkb:MAPK/p38_pathway MAPK/ERK5 pathway |
| gptkbp:memberOf |
gptkb:protein_kinase_superfamily
|
| gptkbp:phosphorylates |
tyrosine residues
serine residues threonine residues |
| gptkbp:proteinFamily |
gptkb:PF00069
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation cell survival gene expression activated by dual phosphorylation regulated by MAPK phosphatases regulated by scaffold proteins regulated by upstream kinases (MAPKKs) |
| gptkbp:relatedTo |
gptkb:cancer
neurodegenerative diseases inflammation immune response cellular response to growth factors cellular response to stress |
| gptkbp:significance |
target for cancer therapy
target for anti-inflammatory drugs |
| gptkbp:subfamily |
gptkb:ERK1/2
gptkb:ERK5 JNK1/2/3 p38α/β/γ/δ |
| gptkbp:UniProtID |
Pkinase
|
| gptkbp:bfsParent |
gptkb:MAP_kinase_family
gptkb:MAPK_family |
| gptkbp:bfsLayer |
7
|