MYB proto-oncogene protein

URI: https://gptkb.org/entity/MYB_proto-oncogene_protein
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:c-Myb
transcriptional activator Myb
gptkbp:associatedWith gptkb:cancer
leukemia
gptkbp:component nuclear chromatin
gptkbp:conservedIn vertebrates
gptkbp:domain DNA-binding domain
transactivation domain
negative regulatory domain
gptkbp:encodedBy gptkb:MYB_gene
gptkbp:expressedIn gptkb:testis
gptkb:thymus
spleen
bone marrow
colon
gptkbp:firstDescribed 1982
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcription factor
DNA-binding transcription factor activity
gptkbp:GOProcess regulation of transcription by RNA polymerase II
gptkbp:HGNC_ID 7545
https://www.w3.org/2000/01/rdf-schema#label MYB proto-oncogene protein
gptkbp:interactsWith gptkb:CDK9
gptkb:CBP
gptkb:Cyclin_D1
gptkb:p300
gptkbp:involvedIn differentiation
cell cycle regulation
proliferation
hematopoiesis
gptkbp:locatedOnChromosome 6q23.3
gptkbp:molecularWeight 75 kDa
gptkbp:mutationAssociatedWith gptkb:acute_myeloid_leukemia
gptkb:T-cell_acute_lymphoblastic_leukemia
gptkbp:orthologIn gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkbp:PDB 1GUU
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:proteinFamily gptkb:MYB_family
gptkbp:regulates apoptosis
cell proliferation
gene expression
differentiation of hematopoietic cells
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID P10242
gptkbp:bfsParent gptkb:MYB_transcription_factor_family
gptkbp:bfsLayer 8