MYB proto-oncogene protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:c-Myb transcriptional activator Myb
gptkbp:associatedWith	gptkb:leukemia gptkb:cancer
gptkbp:component	nuclear chromatin
gptkbp:conservedIn	vertebrates
gptkbp:domain	DNA-binding domain transactivation domain negative regulatory domain
gptkbp:encodedBy	gptkb:MYB_gene
gptkbp:expressedIn	gptkb:testis gptkb:thymus spleen bone marrow colon
gptkbp:firstDescribed	1982
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	gptkb:transcription_factor DNA-binding transcription factor activity
gptkbp:GOProcess	regulation of transcription by RNA polymerase II
gptkbp:HGNC_ID	7545
gptkbp:interactsWith	gptkb:CDK9 gptkb:CBP gptkb:Cyclin_D1 gptkb:p300
gptkbp:involvedIn	differentiation cell cycle regulation proliferation hematopoiesis
gptkbp:locatedOnChromosome	6q23.3
gptkbp:molecularWeight	75 kDa
gptkbp:mutationAssociatedWith	gptkb:acute_myeloid_leukemia gptkb:T-cell_acute_lymphoblastic_leukemia
gptkbp:orthologIn	gptkb:Gallus_gallus gptkb:Mus_musculus
gptkbp:PDB	1GUU
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:proteinFamily	gptkb:MYB_family
gptkbp:regulates	apoptosis cell proliferation gene expression differentiation of hematopoietic cells
gptkbp:subcellularLocation	gptkb:nucleus
gptkbp:UniProtID	P10242
gptkbp:bfsParent	gptkb:MYB_transcription_factor_family
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	MYB proto-oncogene protein