Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
major histocompatibility complex class II molecule |
| gptkbp:alternativeName |
Human Leukocyte Antigen DR
|
| gptkbp:associatedWith |
multiple sclerosis
type 1 diabetes autoimmune diseases rheumatoid arthritis |
| gptkbp:component |
immune system
|
| gptkbp:discoveredIn |
1970s
|
| gptkbp:encodedBy |
HLA-DRA gene
HLA-DRB1 gene |
| gptkbp:expressedIn |
gptkb:B_cells
dendritic cells macrophages antigen-presenting cells |
| gptkbp:foundIn |
humans
|
| gptkbp:function |
antigen presentation
|
| gptkbp:hasAllele |
gptkb:HLA-DR4
HLA-DR1 HLA-DR10 HLA-DR11 HLA-DR12 HLA-DR13 HLA-DR14 HLA-DR15 HLA-DR16 HLA-DR17 HLA-DR18 HLA-DR2 HLA-DR3 HLA-DR5 HLA-DR51 HLA-DR52 HLA-DR53 HLA-DR6 HLA-DR7 HLA-DR8 HLA-DR9 |
| gptkbp:hasPolymorphism |
true
|
| https://www.w3.org/2000/01/rdf-schema#label |
HLA-DR
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_6
|
| gptkbp:location |
cell surface
|
| gptkbp:partOf |
gptkb:HLA_system
|
| gptkbp:recognizedBy |
gptkb:CD4+_T_cells
|
| gptkbp:structure |
heterodimer
|
| gptkbp:subunit |
alpha chain
beta chain |
| gptkbp:usedIn |
disease association studies
transplant compatibility testing |
| gptkbp:bfsParent |
gptkb:MHC_molecule
|
| gptkbp:bfsLayer |
6
|