|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
multiple sclerosis
type 1 diabetes
rheumatoid arthritis
celiac disease
transplant rejection
|
|
gptkbp:encodes
|
gptkb:MHC_class_II_molecules
|
|
gptkbp:expressedIn
|
gptkb:B_cells
dendritic cells
macrophages
activated T cells
antigen-presenting cells
thymic epithelial cells
|
|
gptkbp:expressionDeficiencyCauses
|
gptkb:bare_lymphocyte_syndrome_type_II
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
activate helper T cells
initiate adaptive immune response
present extracellular antigens
|
|
gptkbp:hasPolymorphism
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC class II genes
|
|
gptkbp:include
|
gptkb:HLA-DP
gptkb:HLA-DQ
gptkb:HLA-DR
|
|
gptkbp:inducedBy
|
gptkb:interferon-gamma
|
|
gptkbp:involvedIn
|
antigen presentation
|
|
gptkbp:isTranscribedFrom
|
gptkb:gene
|
|
gptkbp:locatedIn
|
gptkb:major_histocompatibility_complex
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6_(human)
|
|
gptkbp:mutationAssociatedWith
|
autoimmune diseases
|
|
gptkbp:orthologIn
|
gptkb:dog
gptkb:fish
gptkb:mouse
gptkb:cat
birds
right
amphibians
mammals
reptiles
|
|
gptkbp:recognizedBy
|
gptkb:CD4+_T_cells
|
|
gptkbp:regulates
|
gptkb:CIITA
transcription factors
immune response
epigenetic mechanisms
NF-Y
RFX complex
|
|
gptkbp:translatedInto
|
MHC class II proteins
|
|
gptkbp:bfsParent
|
gptkb:MHC_class_II_molecules
|
|
gptkbp:bfsLayer
|
7
|