gptkbp:instanceOf
|
gptkb:gene
|
gptkbp:alsoKnownAs
|
gptkb:ABCB1
P-glycoprotein gene
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Crohn's_disease
gptkb:blood-brain_barrier
colorectal cancer
leukemia
ulcerative colitis
pharmacokinetics
hepatocellular carcinoma
drug distribution
renal cell carcinoma
chemotherapy resistance
adverse drug reactions
drug absorption
drug excretion
HIV drug resistance
epilepsy drug resistance
|
gptkbp:biologicalProcess
|
ATP-dependent drug efflux pump
transports xenobiotics out of cells
protects tissues from toxins
|
gptkbp:discoveredBy
|
gptkb:Victor_Ling
|
gptkbp:discoveredIn
|
1976
|
gptkbp:encodes
|
gptkb:P-glycoprotein
|
gptkbp:Entrez_Gene_ID
|
5243
ENSG00000085563
|
gptkbp:expressedIn
|
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:blood-brain_barrier
liver
intestine
|
gptkbp:function
|
multidrug resistance
drug efflux transporter
|
gptkbp:HGNC_ID
|
40
|
https://www.w3.org/2000/01/rdf-schema#label
|
MDR1 gene
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q21.12
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_(ABC)_transporter_family
|
gptkbp:mutationAssociatedWith
|
altered drug response
|
gptkbp:OMIM
|
171050
|
gptkbp:orthologInMouse
|
Abcb1a
Abcb1b
|
gptkbp:product
|
P-glycoprotein (ABCB1)
|
gptkbp:UniProtID
|
P08183
|
gptkbp:bfsParent
|
gptkb:MDR1_gene_mutation
|
gptkbp:bfsLayer
|
6
|