MDR1 gene

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:ABCB1
P-glycoprotein gene
gptkbp:associatedWith gptkb:cancer
gptkb:Crohn's_disease
gptkb:blood-brain_barrier
colorectal cancer
leukemia
ulcerative colitis
pharmacokinetics
hepatocellular carcinoma
drug distribution
renal cell carcinoma
chemotherapy resistance
adverse drug reactions
drug absorption
drug excretion
HIV drug resistance
epilepsy drug resistance
gptkbp:biologicalProcess ATP-dependent drug efflux pump
transports xenobiotics out of cells
protects tissues from toxins
gptkbp:discoveredBy gptkb:Victor_Ling
gptkbp:discoveredIn 1976
gptkbp:encodes gptkb:P-glycoprotein
gptkbp:Entrez_Gene_ID 5243
ENSG00000085563
gptkbp:expressedIn gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:blood-brain_barrier
liver
intestine
gptkbp:function multidrug resistance
drug efflux transporter
gptkbp:HGNC_ID 40
https://www.w3.org/2000/01/rdf-schema#label MDR1 gene
gptkbp:locatedOnChromosome gptkb:chromosome_7
7q21.12
gptkbp:memberOf gptkb:ATP-binding_cassette_(ABC)_transporter_family
gptkbp:mutationAssociatedWith altered drug response
gptkbp:OMIM 171050
gptkbp:orthologInMouse Abcb1a
Abcb1b
gptkbp:product P-glycoprotein (ABCB1)
gptkbp:UniProtID P08183
gptkbp:bfsParent gptkb:MDR1_gene_mutation
gptkbp:bfsLayer 6