Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:affects |
gptkb:MDR1_gene
|
| gptkbp:alsoKnownAs |
gptkb:ABCB1_gene_mutation
|
| gptkbp:associatedWith |
adverse drug reactions
|
| gptkbp:cause |
multidrug resistance
increased drug sensitivity neurotoxicity from ivermectin toxicity from certain chemotherapy drugs toxicity from loperamide |
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
gptkb:dog
humans |
| https://www.w3.org/2000/01/rdf-schema#label |
MDR1 gene mutation
|
| gptkbp:impact |
P-glycoprotein function
drug transport across blood-brain barrier |
| gptkbp:inheritsFrom |
autosomal recessive trait
|
| gptkbp:notableFor |
Australian Shepherds
Collie dogs Shetland Sheepdogs |
| gptkbp:result |
reduced drug efflux
|
| gptkbp:testedBy |
genetic testing
|
| gptkbp:bfsParent |
gptkb:Australian_Shepherd
|
| gptkbp:bfsLayer |
5
|